new paper from zallen lab about the role of Fat cadherin and Hippo pathway in planar polarization in the epidermis of late drosophila embryos

nice review by st.johnston comparing the different genetical tools/techniques used in drosophila

CP

Couple of nice papers out.. just in case you missed them!
CPs back-to-back in Science.. on adhesion and forces... (i haven't read them, but they must be good, it's CP!! Maybe we should tell him our latest data on integrins and E-cadherin turn over...)
and Brian Stramer paper on contact inhibition is finally out. A shame to see it didn't make into Science.

Review on the JNK pathway

review about the JNK pathway in flies, talking about dorsal closure, thorax closure, etc...

special issue of seminars cell dev. biol.

about wound repair and regeneration

role of actin cable and protrusions during wound closure in the fly embryo

new paper by the parkhurst lab showing a detailed characterization of the wound healing process in fly embryonic epidermis

GCaMP5

GCaMP5 - an improved calcium indicator

modeling ventral furrow formation, by leptin and colleagues

wound healing review

new review on wound healing focusing on the cytoskeleton, by Parkhurst and colleagues

new paper by the galko lab...

...showing that JNK activates the transcription of profilin during wound healing in the larva

actin disassembly factor

I never really paid much attention to this flare/AIP1 guy.
But a new paper is out showing its role in AJ remodeling... wound healing? Wave? Froggies?

keep up with the blog

here's some smoooth jazz for the winter to come..

nice images

Imaging Course

If anyone is interested in attending an Imaging Course, this is the course to attend!!

 I have never seen such an amazing line-up of speakers...
 The deadline for registration is on the 15th of September although the course is only October next year.

multicolor imaging using two-photon microscopy

paper showing that ecadherin cytoplasmic domain is indeed a molecular sensor for tension (they used a FRET sensor). they also saw that this is dependent on alpha-catenin and actin. and interestingly they found that this force-sensing property of e-cadherin is important not only in cell-cell contacts but also cell contact-free regions.

a review on transcription factors induced by mechanical stress. they talk about interesting molecules for many of us (YAP, NKkappaB, catenins...;)

short review on the piezo proteins

paper showing that H2O2 formed upon injury leads to disruption of epithelial barrier/disassembly of TJs and AJs via Gα12 and Src, both in MDCK cells and mice

special issue of nature methods on quantitative microscopy!!

epithelial resealing in the absence of injury not dependent on actomyosin purse-string

a new PNAS paper analyzing epithelial resealing in the absence of a "wound"! this paper shows that the closure of a gap in an epithelial cell monolayer does not require the purse-string mechanism and is more dependent on cell crawling/lamellipodia formation!

Inês paper in Cancer Cell

So Inês T already have a paper in Cancer Cell.. now that was quick.
Congrats...

Bri paper on Fascin/singed

Bri's paper on Fascin/singed is out in JCB..
He characterised a new phosphorylation site, which is very interesting. The "classical" serine52 is not bundling actin when phosphorylated, and has been described before.
But this one (serine289) is at the tip of filaments when not phosphorylated. Could be interesting to see what happens when both sides are mutated.

cell migration screen

rnai screen identifying new genes involved in cell migration and cytoskeleton organization

Sara's paper cited

A paper out in DevCell on regeneration of Zebrafish Fin Rays citing Sara's paper...

Epithelia Delamination

Two papers on epithelia delamination, one in flies from Buzz (the talk he gave at the EMBO meeting) and on in zebrafish and in vitro from Jody.
Nice!

Dark Fly

These guys kept a fly stock in the dark for 57 years!! Not exactly a Master’s project, if you have to wait for 57 years!! Now who thought 57 years ago that this could be and interesting and very important experiment?! And imagine if someone entered the room one day and turned the lights on by mistake!!

Now they published the genome sequence, and I am not convinced considering that next-generation sequencing is not good enough yet, and they compare the sequence to Oregon R. But the idea is crazy enough!!

review on regeneration

interesting review on regeneration in different model organisms

phd survival guide

a few good good advices...(?)

drosophila developmental stages

Here is a very precise and useful decription of every developmental stage from embryos to pupae.

Tension on Cadherin induce Polarity

A new paper out in DevCell showing that tension on Cadherin via intermediate filament (for once not actin), is enforcing polarity; by pulling in the back, the cells will respond my migrating the other direction. In other words (and not shown in the paper), in a wound site, the leading edge cells are polarised towards the wound by being pulled (via cadherin) from the cells behind it. A "mechanoresponse" that will induce migration to close the wound.

Drawing is taken from Dev Cell

analysis of hemocyte behavior ex-vivo

will is on top

comment about the c.elegans paper on calcium at wounds and future perspectives...

Yet another Banerjee cell paper

Brilliant Cell paper from Banerjee showing the signaling pathways and feedback loops in the lymph gland. Particularly, how the posterior signaling center signal to the medullary zone and the cortical zone, and the feedback mechanism to maintain  progenitor  cell  quiescence. Really nice piece showing the strength of using the lymph gland to study stem cell niche.